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The Expanding Landscape of Alternative Splicing Variation in Human Populations.
Alternative splicing is a tightly regulated biological process by which the number of gene products for any given gene can be greatly expanded. Genomic variants in splicing regulatory sequences can disrupt splicing and cause disease. Recent developments in sequencing technologies and computational biology have allowed researchers to investigate alternative splicing at an unprecedented scale and resolution. Population-scale transcriptome studies have revealed many naturally occurring genetic variants that modulate alternative splicing and consequently influence phenotypic variability and disease susceptibility in human populations. Innovations in experimental and computational tools such as massively parallel reporter assays and deep learning have enabled the rapid screening of genomic variants for their causal impacts on splicing. In this review, we describe technological advances that have greatly increased the speed and scale at which discoveries are made about the genetic variation of alternative splicing. We summarize major findings from population transcriptomic studies of alternative splicing and discuss the implications of these findings for human genetics and medicine
Product Diversity and Firm Performance on O2O Platforms
This paper studies the decision of product diversity by firms on digital platforms, and the impact of the decisions on the performance of the firms. Specifically, we take the cinema as the unit of analysis, and study the influence of the diversity of movie scheduling on cinema performance in the context of O2O (online-to-offline) platforms. The results show that the diversity of movie scheduling has a significant negative impact on box office revenues and attendance. The ratio of consumers’ adoption of O2O platforms significantly and negatively moderates the main effect. That is, the higher the online ratio is, the weaker the influence of movie-scheduling diversity on cinema performance. Implications of findings are discussed
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